What I take back home apart of\u00a0<\/span><\/span>t<\/span>he knowledge that<\/span>\u00a0<\/span>I acquired is the vast number of friends and professionals that I met and that I will keep forever with me.\u00a0<\/span><\/span>\u00a0<\/span><\/h3>\n<\/blockquote>\n<\/h2>\n\n\t\t\n\t\t\t\n\t\t\t\t\n\t\t\t
\n\t\t\t<\/div>\n\t\t<\/div> \n\t\t\n\t\t\tHello everyone!\u00a0<\/span><\/span><\/span>This is Claudio Fernandez Mart\u00edn, ESR6 at<\/span>\u00a0<\/span>CLARIFY.\u00a0<\/span><\/span>Today I am going to tell you all about my experience during my three-month Secondment at the Stavanger University Hospital (SUH) in Norway.<\/span><\/span>\u00a0<\/span>\n\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n <\/p>\n
When I was reviewing the pictures from my time in Norway to include in this blog post I could not avoid getting a bit nostalgic. I had a great time during my three-month Secondment at the Stavanger University Hospital (SUH) in Norway. This stay was my first in-person Secondment within the CLARIFY network and it could not have been any better. I learnt very valuable insights about pathology from Emiel Janssen, one of the best TNBC researchers in the world, and I have shared unforgettable experiences with people that I met in Stavanger, and that now I am lucky to consider my friends.<\/span>\u00a0<\/span><\/p>\nDuring the first days of my Secondment I met Umay Kiraz (ESR6) and since the very first minute she offered herself to help me in all possible ways, both academic and personal. The first two weeks with her I learnt how pathologists examine and evaluate the biopsies in order to come up with the final grading and the report. This was a crucial point not only from my Secondment but for my PhD in general, as it really helped me to understand what were the most important features to look at when facing a breast biopsy (or in my case a Whole-Slide Image). Thanks to Umay I learnt about the mitotic cycle and how to determine whether a\u00a0nucleus\u00a0is mitotic or not and to obtain the Mitotic Activity Index (MAI), I learnt to distinguish tumor cells from other nuclei and I learnt how to count and evaluate the Tumor Infiltrating\u00a0Lymphocytes\u00a0(TILs). Also, she taught me the importance of immunohistochemistry for pathologists, as thanks to different antibodies\u00a0and a special staining applied to a biopsy it is possible, for instance, to observe only the cells that are in a particular phase of the cell cycle, like Ki-67 or PPH-3. This is particularly interesting for my project, as I am currently dealing with mitoses detection and these staining can mark as positive cells that are in a mitotic state, and therefore, they are used as proliferation markers that help to stratify between good and poor prognostic categories in invasive breast cancer.<\/span>\u00a0<\/span><\/p>\nIn\u00a0my\u00a0first\u00a0days in SUH I learnt the whole Whole-Slide Image (WSI) digitalization workflow from the extraction of the biopsy, the\u00a0paraffin\u00a0block creation, cutting and scanning. Also, throughout my three months I received several lectures from Emiel\u00a0about Digital Pathology and learnt about its history, advances and challenges. He also taught me about Quantitative Pathology and the biomarkers used for diagnosis and prognosis of Breast Cancer, specifically about the histopathology of Triple Negative Breast Cancer (TNBC).\u00a0I also learnt about the latest technologies and techniques in cancer research such as the Hyperion and the\u00a0Nanostring\u00a0geoMx\u00a0together with an introduction about molecular pathology.<\/span>\u00a0<\/span><\/p>\nIn the Secondment I had the chance to attend the research meetings from both the SUH and the BMDLab at the University of Stavanger (UiS) directed by\u00a0Kjersti\u00a0Engan. In these meetings I presented my work regularly and I received feedback from both medical personnel at the hospital and from AI and data science researchers at the university. Both perspectives helped me gain a much deeper understanding about the needs and possibilities in both aspects of my project, while I gained a lot of confidence and presentation skills as I had to present my progress to two completely different audience groups.<\/span>\u00a0<\/span><\/p>\nOverall, in this Secondment I learnt very important medical aspects of TNBC and Digital Pathology at\u00a0SUH while\u00a0also benefitting from the technical insight from the BMDLab PhD students and researchers.\u00a0Nonetheless<\/span>, what I take back home apart of\u00a0the knowledge that\u00a0I acquired is the vast number of friends and professionals that I met and that I will keep forever with me.<\/p>\n![\"\"](\"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-content\/uploads\/2022\/01\/umay-and-claudio-microscope-1-300x225.jpeg\")
<\/span><\/p>\nFigure\u00a0<\/span><\/span>1<\/span><\/span><\/span>. ESR6, Claudio Fernandez and ESR11, Umay Kiraz, together with the WSI scanner.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n![\"\"](\"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-content\/uploads\/2022\/01\/1st-day-with-uis-clarify-300x225.jpeg\")
<\/span><\/p>\nFigure\u00a0<\/span><\/span>2<\/span><\/span><\/span>. Picture\u00a0<\/span>with<\/span>\u00a0Emiel\u00a0<\/span>Jansseen<\/span>, ESR5 (<\/span>Saul Fuster<\/span>), ESR6 (Claudio Fernandez), ESR9 (Zahra\u00a0<\/span>Tabatabaei<\/span>), ESR 11 (Umay Kiraz) and Fernando\u00a0<\/span>Perez<\/span>\u00a0Bueno.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n![\"\"](\"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-content\/uploads\/2022\/01\/fjord-with-emiel-elisa-zahra-and-umayu-300x225.jpeg\")
<\/span><\/p>\nFigure\u00a0<\/span><\/span>3<\/span><\/span><\/span>.\u00a0<\/span>Excursion<\/span>\u00a0<\/span>to<\/span>\u00a0<\/span>M\u00e5nafossen<\/span>.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n![\"\"](\"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-content\/uploads\/2022\/01\/preikestolen-claudito-225x300.jpeg\")
<\/span><\/p>\nFigure\u00a0<\/span><\/span>4<\/span><\/span><\/span>. Me at the Pulpit Rock (<\/span>Preikestolen<\/span>).<\/span><\/span>\u00a0<\/span><\/span><\/p>\n![\"\"](\"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-content\/uploads\/2022\/01\/birthday-party-clarify-uis-300x225.jpeg\")
<\/span><\/p>\nFigure\u00a0<\/span><\/span>5<\/span><\/span><\/span>. Celebrating my birthday with friends from CLARIFY and from the University of Stavanger in Norway.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n<\/span><\/span><\/p>\nClaudio Fern\u00e1ndez – ESR6.<\/span><\/span><\/em><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Hello everyone! This is Claudio Fernandez Mart\u00edn, ESR6 at CLARIFY. Today I am going to tell you all about my experience during my three-month Secondment at the Stavanger University Hospital (SUH) in Norway. <\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_eb_attr":"","footnotes":""},"categories":[11],"tags":[],"class_list":["post-2801","post","type-post","status-publish","format-standard","hentry","category-secondment"],"_links":{"self":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/posts\/2801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/comments?post=2801"}],"version-history":[{"count":0,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/posts\/2801\/revisions"}],"wp:attachment":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/media?parent=2801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/categories?post=2801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/tags?post=2801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\t\t\t<\/p>\n
When I was reviewing the pictures from my time in Norway to include in this blog post I could not avoid getting a bit nostalgic. I had a great time during my three-month Secondment at the Stavanger University Hospital (SUH) in Norway. This stay was my first in-person Secondment within the CLARIFY network and it could not have been any better. I learnt very valuable insights about pathology from Emiel Janssen, one of the best TNBC researchers in the world, and I have shared unforgettable experiences with people that I met in Stavanger, and that now I am lucky to consider my friends.<\/span>\u00a0<\/span><\/p>\n During the first days of my Secondment I met Umay Kiraz (ESR6) and since the very first minute she offered herself to help me in all possible ways, both academic and personal. The first two weeks with her I learnt how pathologists examine and evaluate the biopsies in order to come up with the final grading and the report. This was a crucial point not only from my Secondment but for my PhD in general, as it really helped me to understand what were the most important features to look at when facing a breast biopsy (or in my case a Whole-Slide Image). Thanks to Umay I learnt about the mitotic cycle and how to determine whether a\u00a0nucleus\u00a0is mitotic or not and to obtain the Mitotic Activity Index (MAI), I learnt to distinguish tumor cells from other nuclei and I learnt how to count and evaluate the Tumor Infiltrating\u00a0Lymphocytes\u00a0(TILs). Also, she taught me the importance of immunohistochemistry for pathologists, as thanks to different antibodies\u00a0and a special staining applied to a biopsy it is possible, for instance, to observe only the cells that are in a particular phase of the cell cycle, like Ki-67 or PPH-3. This is particularly interesting for my project, as I am currently dealing with mitoses detection and these staining can mark as positive cells that are in a mitotic state, and therefore, they are used as proliferation markers that help to stratify between good and poor prognostic categories in invasive breast cancer.<\/span>\u00a0<\/span><\/p>\n In\u00a0my\u00a0first\u00a0days in SUH I learnt the whole Whole-Slide Image (WSI) digitalization workflow from the extraction of the biopsy, the\u00a0paraffin\u00a0block creation, cutting and scanning. Also, throughout my three months I received several lectures from Emiel\u00a0about Digital Pathology and learnt about its history, advances and challenges. He also taught me about Quantitative Pathology and the biomarkers used for diagnosis and prognosis of Breast Cancer, specifically about the histopathology of Triple Negative Breast Cancer (TNBC).\u00a0I also learnt about the latest technologies and techniques in cancer research such as the Hyperion and the\u00a0Nanostring\u00a0geoMx\u00a0together with an introduction about molecular pathology.<\/span>\u00a0<\/span><\/p>\n In the Secondment I had the chance to attend the research meetings from both the SUH and the BMDLab at the University of Stavanger (UiS) directed by\u00a0Kjersti\u00a0Engan. In these meetings I presented my work regularly and I received feedback from both medical personnel at the hospital and from AI and data science researchers at the university. Both perspectives helped me gain a much deeper understanding about the needs and possibilities in both aspects of my project, while I gained a lot of confidence and presentation skills as I had to present my progress to two completely different audience groups.<\/span>\u00a0<\/span><\/p>\n Overall, in this Secondment I learnt very important medical aspects of TNBC and Digital Pathology at\u00a0SUH while\u00a0also benefitting from the technical insight from the BMDLab PhD students and researchers.\u00a0Nonetheless<\/span>, what I take back home apart of\u00a0the knowledge that\u00a0I acquired is the vast number of friends and professionals that I met and that I will keep forever with me.<\/p>\n Figure\u00a0<\/span><\/span>1<\/span><\/span><\/span>. ESR6, Claudio Fernandez and ESR11, Umay Kiraz, together with the WSI scanner.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n Figure\u00a0<\/span><\/span>2<\/span><\/span><\/span>. Picture\u00a0<\/span>with<\/span>\u00a0Emiel\u00a0<\/span>Jansseen<\/span>, ESR5 (<\/span>Saul Fuster<\/span>), ESR6 (Claudio Fernandez), ESR9 (Zahra\u00a0<\/span>Tabatabaei<\/span>), ESR 11 (Umay Kiraz) and Fernando\u00a0<\/span>Perez<\/span>\u00a0Bueno.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n Figure\u00a0<\/span><\/span>3<\/span><\/span><\/span>.\u00a0<\/span>Excursion<\/span>\u00a0<\/span>to<\/span>\u00a0<\/span>M\u00e5nafossen<\/span>.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n Figure\u00a0<\/span><\/span>4<\/span><\/span><\/span>. Me at the Pulpit Rock (<\/span>Preikestolen<\/span>).<\/span><\/span>\u00a0<\/span><\/span><\/p>\n Figure\u00a0<\/span><\/span>5<\/span><\/span><\/span>. Celebrating my birthday with friends from CLARIFY and from the University of Stavanger in Norway.<\/span><\/span>\u00a0<\/span><\/span><\/p>\n <\/span><\/span><\/p>\n Claudio Fern\u00e1ndez – ESR6.<\/span><\/span><\/em><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Hello everyone! This is Claudio Fernandez Mart\u00edn, ESR6 at CLARIFY. Today I am going to tell you all about my experience during my three-month Secondment at the Stavanger University Hospital (SUH) in Norway. <\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_eb_attr":"","footnotes":""},"categories":[11],"tags":[],"class_list":["post-2801","post","type-post","status-publish","format-standard","hentry","category-secondment"],"_links":{"self":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/posts\/2801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/comments?post=2801"}],"version-history":[{"count":0,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/posts\/2801\/revisions"}],"wp:attachment":[{"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/media?parent=2801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/categories?post=2801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cvblab.webs.upv.es\/clarify-project.eu\/wp-json\/wp\/v2\/tags?post=2801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\n